Innate immunity and pathology of the critical patient

Rafael Mañez Mendiluce

PRINCIPAL INVESTIGATORS
  • Joan Sabater Riera
CLINICAL RESEARCHERS
  • Luisa Corral Ansa
  • Maria Paz Fuset Cabanes
  • Francesc Esteve Urbano
  • Eva Oliver Juan
  • Xosé Luis Pérez Fernández
  • Gabriel Jesus Moreno González
  • Ana Rosa Ochagavía Calvo
POSTDOCTORAL RESEARCHERS
  • Sara Olivera Ardid
PREDOCTORAL RESEARCHERS
  • Ricard Soley Corderas
  • Victor Daniel Gumucio Sanguino
Translational Medicine
Infectious disease and transplantation

Scientific production

15

PAPERS

Average IF: 9,653

8

LED PAPERS

Average IF: 4,987

4 PUBLICATIONS IN FIRST DECILE

10 PUBLICATIONS IN FIRST QUARTILE

13 PUBLICATIONS IN OPEN ACCESS

Selected publications

  • Galli,F;Bindo,F;Motos,A;Fernandez Barat,L;Barbeta,E;Gabarrus,A;Ceccato,A et al, Procalcitonin and C-reactive protein to rule out early bacterial coinfection in COVID-19 critically ill patients, Intensive Care Med., 2023;49(8):934-945, doi:10.1007/s00134-023-07161-1
  • Riera,J;Barbeta,E;Tormos,A;Mellado Artigas,R;Ceccato,A;Motos,A;Fernandez Barat,L et al, Effects of intubation timing in patients with COVID-19 throughout the four waves of the pandemic: a matched analysis, Eur. Resp. J., 2023;61(3):doi:10.1183/13993003.01426-2022
  • Pérez Galera,S;Bravo Ferrer,JM;Paniagua,M;Kostyanev,T;de Kraker,M;Feifel,J;Sojo Dorado,J et al, Risk factors for infections caused by carbapenem-resistant Enterobacterales: an international matched case-control-control study (EURECA)., EClinicalMedicine, 2023;57101871-101871, doi:10.1016/j.eclinm.2023.101871
  • Matuozzo,D;Talouarn,E;Marchal,A;Zhang,P;Manry,J;Seeleuthner,Y;Zhang,Y et al, Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19., Genome Med., 2023;15(1):22-22, doi:10.1186/s13073-023-01173-8
  • Olivera Ardid,S;Bello Gil,D;Perez Cruz,M;Costa,C;Camoez,M;Dominguez,MA;Ferrero Alves,Y et al, Removal of natural anti-aGal antibodies elicits protective immunity against Gram-negative bacterial infections, Front. Immunol., 2023;141232924-1232924, doi:10.3389/fimmu.2023.1232924

Research highlights

PROJECTS

2 Ongoing competitive projects
4 Ongoing non competitive projects

2 Started clinical trials
6 Ongoing clinical trials

PUBLISHED WORKS

1 Clinical guideline

INNOVATION

2 Patents
2 Licenses
1 spin-off 

Selected projects

  • 2022-311-1. ESTUDIO MULTICÉNTRICO, ALEATORIZADO, DOBLE CIEGO (PARTICIPANTE E INVESTIGADOR) Y CONTROLADO CON PLACEBO EN EL QUE SE EVALÚAN LA SEGURIDAD, LA TOLERABILIDAD Y LA EFICACIA DE TIN816 EN PACIENTES ADULTOS CON RIESGO DE LESIÓN RENAL AGUDA TRAS UNA CIRUGÍA CARDÍACA. Novartis Farmacéutica, S.A. Budget: 123.832€. 2023- . PI: Sabater Riera, Joan.
  • 20CEE013. ENVISION: Intelligent plug-and-play digital tool for real-time surveillance of COVID-19 patients and smart decision-making in Intensive Care Units. COMISSIÓ EUROPEA. Budget: 115.000€. 2020-2023. PI: Máñez Mendiluce, Rafael.
  • CEE21011. COVend: Biomarker and AI-supported FX06 therapy to prevent progression from mild and moderate to severe stages of COVID-19. COMISSIÓ EUROPEA. Budget: 114.101,66€. 2021-2024. PI: Máñez Mendiluce, Rafael.
  • 2023-472-1. ESTUDIO DE VALIDACIÓN DEL TEST SEPTILOOP LATERAL FLOW ASSAY EN PACIENTES SÉPTICOS. ESTUDIO PROSPECTIVO OBSERVACIONAL. LOOP DIAGNOSTICS SL. Budget: 42.000€. 2023- . PI: Sabater Riera, Joan.
  • 2022-208-1. ESTUDIO DE FASE IIA, MULTICÉNTRICO, DOBLE CIEGO (PARTICIPANTE E INVESTIGADOR), ALEATORIZADO Y CONTROLADO CON PLACEBO EN EL QUE SE INVESTIGAN LA FARMACOCINÉTICA, LA FARMACODINÁMICA, LA SEGURIDAD Y LA TOLERABILIDAD DE TIN816 EN EL TRATAMIENTO DE PACIENTES CON LESIÓN RENAL AGUDA ASOCIADA A SEPSIS. Novartis Farmacéutica, S.A. Budget: 15.424€. 2022- . PI: Sabater Riera, Joan.