Resistance and progression mechanisms in prostate cancer

Alvaro Aytés Meneses

PRINCIPAL INVESTIGATORS
  • Mireia Olivan Riera
CLINICAL RESEARCHERS
  • Maria Pane Foix
  • Manuel Maria Castells Esteve
  • Jose Francisco Suarez Novo
  • Natàlia Picola Brau
POSTDOCTORAL RESEARCHERS
  • Lidia Franco Luzon
  • Adrian Martinez Tébar
  • Ana Sofia Semiao Correia Da Rocha
  • Rana El Bizri
PREDOCTORAL RESEARCHERS
  • Javier Sigüenza Andrade
  • Pilar Salamanca Jimenez
SCIENTIFIC SUPPORT
  • Nadia García Lozano
Cancer
Oncobell

Scientific production

11

PAPERS

Average IF: 5,582

6

LED PAPERS

Average IF: 6,933

2 PUBLICATIONS IN FIRST DECILE

3 PUBLICATIONS IN FIRST QUARTILE

8 PUBLICATIONS IN FIRST QUARTILE

Selected publications

  • Rocha,AS;Collado Solé,A;Graña Castro,O;Redondo Pedraza,J;Soria Alcaide,G;Cordero,A;Santamaria,PG et al, Luminal Rank loss decreases cell fitness leading to basal cell bipotency in parous mammary glands, Nat. Commun., 2023;14(1):6213-6213, doi:10.1038/s41467-023-41741-5
  • Alegre Marti,A;Jimenez Panizo,A;Martinez Tebar,A;Poulard,C;Peralta Moreno,MN;Abella,M;Anton,R et al, A hotspot for posttranslational modifications on the androgen receptor dimer interface drives pathology and anti-androgen resistance, Sci. Adv., 2023;9(11):doi:10.1126/sciadv.ade2175
  • Creus Bachiller,E;Fernández Rodríguez,J;Magallón Lorenz,M;Ortega Bertran,S;Navas Rutete,S;Romagosa,C;Silva,TM et al, Expanding a precision medicine platform for malignant peripheral nerve sheath tumors: New patient-derived orthotopic xenografts, cell lines and tumor entities, Mol. Oncol., 2023;18(4):895-917, doi:10.1002/1878-0261.13534
  • Morote,J;Picola,N;Muñoz Rodriguez,J;Paesano,N;Ruiz Plazas,X;Muñoz Rivero,MV;Celma,A et al, A Diagnostic Accuracy Study of Targeted and Systematic Biopsies to Detect Clinically Significant Prostate Cancer, including a Model for the Partial Omission of Systematic Biopsies, Cancers, 2023;15(18):doi:10.3390/cancers15184543
  • Hanna,MY;Winterbone,M;O’Connell,SP;Olivan,M;Hurst,R;Mills,R;Cooper,CS et al, Gene-Transcript Expression in Urine Supernatant and Urine Cell-Sediment Are Different but Equally Useful for Detecting Prostate Cancer, Cancers, 2023;15(3):doi:10.3390/cancers15030789

Research highlights

PROJECTS

2 Granted competitive projects
9 Ongoing competitive projects

3 Ongoing clinical trials
1 Ongoing non competitive project

PUBLISHED WORKS

1 Thesis

NETWORKS

AGAUR – SGR
MIN-RE – Red de Excelencia

Selected projects

  • USA21005. Dissecting the role of cancer cell chromatin remodeling on the landscape of tumor immune microenvironment. DEPARTMENT OF DEFENSE. Budget: 465.431,26€. 2022-2025. PI: AYTES MENESES, ALVARO.
  • 18INT004. Mechanisms ant therapeutic targeting of NSD2 in advanced prostate cancer. DEPARTMENT OF DEFENSE. Budget: 352.372,94€. 2018-2023. PI: AYTES MENESES, ALVARO.
  • AEC21002. Dissecting EZH2-SWI/SNF antagonism to target cell plasticity in therapy resistant prostate cancer. Asociación Española Contra el Cáncer (AECC). Budget: 299.363,42€. 2021-2024. PI: AYTES MENESES, ALVARO.
  • 20FIS003. Therapeutic landscape and predictive biomarkers for DNA damage repair pathway inhibitors in advanced prostate cancer. Instituto de Salud Carlos III (ISCIII). Budget: 255.310€. 2020-2024. PI: AYTES MENESES, ALVARO.
  • FIS23035. Inhibición de la señalización mediada por ROS para superar la resitencia a antiandrógenos e immunoterápia en cáncer de próstata resistente a la castración. Instituto de Salud Carlos III (ISCIII). Budget: 233.750. 2024-2026. PI: AYTES MENESES, ALVARO.